Publications

Journals Papers

• Martínez-Jiménez JE, Ortega-Lampón Y, Cedres-Rivera D, Heredia-Negrón F, Roche-Lima A, Duconge J. Leveraging Machine Learning to Predict Warfarin Sensitivity in the Puerto Rican Population: A Pharmacogenomic Approach. Int J Environ Res Public Health. 2026 Mar 7;23(3):337. doi: 10.3390/ijerph23030337.
• Aponte Ramos L, Pena Díaz X, Cruz Sánchez RM, Rodríguez De Jesús AE, Cantres Rosario YM, Tosado Rodríguez EL, Roche Lima A, Meléndez LM, Chiesa R. Neuroproteomic Profiling of the Anxiolytic Potential of Stypopodium zonale in Drosophila. Int J Mol Sci. 2026 Feb 27;27(5):2240. doi: 10.3390/ijms27052240.
• Irizarry-Méndez N, Acosta-Pierantoni Y, Diaz-Vazquez A, Hernández A, Colón M, Tosado-Rodríguez EL, Cantres-Rosario YM, Roche-Lima A, Rodríguez-De Jesús AE, Meléndez LM, Porter JT. Proteomic insights into extinction memory deficits in stress-susceptible female rats. Front Behav Neurosci. 2026 Jan 13;19:1703714. doi: 10.3389/fnbeh.2025.1703714. eCollection 2025.
• LeBien J, Velev J, Roche-Lima A. RINet: synthetic data training for indirect estimation of clinical reference distributions. J Biomed Inform. 2026 Feb;174:104980. doi: 10.1016/j.jbi.2026.104980. Epub 2026 Jan 8.
• Heredia-Negrón F, Nagamatsu ST, Carrasquillo-Carrion K, Hurd Y, Rompala G, Melín K, Garcia-Vassallo G, Roche-Lima A, Montalvo-Ortiz JL. Building epigenetic risk scores of opioid use disorder: Insights from human postmortem brain data. Transl Psychiatry. 2026 Jan 9;16(1):62. doi: 10.1038/s41398-025-03792-8.
• Betancourt J, Betancourt E, Roche-Lima A, Velev J. Chronic Disease Monitoring: Methodology for Classification Error and Self-Selection Bias Correction in Clinical Laboratory Data. Healthcare (Basel). 2025 Nov 25;13(23):3056. doi: 10.3390/healthcare13233056.
• Marrero Valentín JL, Tosado-Rodríguez EL, Carrasquillo Carrión K, Pérez D, Roche Lima A, Ferchmin PA, Sabeva N. Modeling Gulf War Illness: anxiety, memory deficits, cholinergic and potassium channel imbalance in male and female mice. Life Sci. 2025 Nov 1;380:123901. doi: 10.1016/j.lfs.2025.123901. Epub 2025 Aug 14.
• Rosario-Rodríguez LJ, Cantres-Rosario YM, Rodríguez De Jesús AE, Mera-Pérez AM, Tosado-Rodríguez EL, Roche Lima A, Meléndez LM. Cannabinoid Receptor Type 2 Agonist JWH-133 Stimulates Antiviral Factors and Decreases Proviral, Inflammatory, and Neurotoxic Proteins in HIV-Infected Macrophage Secretome. Int J Mol Sci. 2025 Oct 30;26(21):10596. doi: 10.3390/ijms262110596.
• Orellano-Colón EM, Bonilla-Díaz W, Revilla-Orellano R, Mejías-Castro J, Roche-Lima A. Quality of an Assistive Technology Web Application for Primary Care Physicians Serving Older Adults: Concurrent Mixed Methods Study. JMIR Form Res. 2025 Oct 22;9:e69645. doi: 10.2196/69645.
• Morales-Cabán BM, Cantres-Rosario YM, Tosado-Rodríguez EL, Roche-Lima A, Meléndez LM, Boukli NM, Suarez-Arroyo IJ. SCAMP3-Driven Regulation of ERK1/2 and Autophagy Phosphoproteomics Signatures in Triple-Negative Breast Cancer. Int J Mol Sci. 2025 Oct 1;26(19):9577. doi: 10.3390/ijms26199577.
• Velev J, Velázquez-Sosa L, LeBien J, Janwa H, Roche-Lima A. Modeling Multivariate Distributions of Lipid Panel Biomarkers for Reference Interval Estimation and Comorbidity Analysis. Healthcare (Basel). 2025 Oct 1;13(19):2499. doi: 10.3390/healthcare13192499.
• Armina-Rodriguez A, Valdés Fernandez BN, Ocasio-Malavé C, Cantres Rosario YM, Carrasquillo Carrión K, Meléndez LM, Roche Lima A, Tosado Rodriguez EL, Espino AM. Quantitative Proteomics Reveals Fh15 as an Antagonist of TLR4 Downregulating the Activation of NF-κB, Inducible Nitric Oxide, Phagosome Signaling Pathways, and Oxidative Stress of LPS-Stimulated Macrophages. Int J Mol Sci. 2025 Jul 18;26(14):6914. doi: 10.3390/ijms26146914.
• Lloret Torres ME, Rivas Jiménez A, Tosado Rodríguez EL, Cardona Jordan K, Lay Rivera XX, Peña Señeriz YL, Capella Muñiz JL, Dieppa Rodríguez M, Ruiz Bolívar DF, González Del Toro J, Florian Alsina JA, Colón Rivera PA, Garcia Colon JO, Roche-Lima A, Velázquez-Marrero C. Comparative mRNA profile analysis from NAc of adolescent male mice after binge-like alcohol exposure eliciting deficits in context fear extinction learning. PLoS One. 2025 Jun 25;20(6):e0322576. doi: 10.1371/journal.pone.0322576. eCollection 2025.
• Yang G, González P, Moneró M, Carrasquillo K, Renta JY, Hernandez-Suarez DF, Botton MR, Melin K, Scott SA, Ruaño G, Roche-Lima A, Alarcon C, Ritchie MD, Perera MA, Duconge J. Discovery of ancestry-specific variants associated with clopidogrel response among Caribbean Hispanics. NPJ Genom Med. 2025 Mar 7;10(1):20. doi: 10.1038/s41525-025-00479-3.
• Alicia SV, Rivera-Moctezuma FG, Marrero Valentín JL, Pérez D, Tosado-Rodríguez EL, Roche Lima A, Ferchmin PA, Sabeva N. Neuroprotection by 4R-cembranoid against Gulf War Illness-related Chemicals is mediated by ERK, PI3K, and CaMKII pathways. Neuropharmacology. 2025 Feb 15;264:110199. doi: 10.1016/j.neuropharm.2024.110199. Epub 2024 Oct 22.
• Orellano-Colón EM, Ramos-Marichal AI, González-Crespo VR, Zeballos-Hernández BN, Ruiz-Márquez KN, Roche-Lima A, Adorno-Mercado JM, Laborde-Torres NA, Berríos-Llopart JG, Cruz-Ramos AM, Montenegro DV, Lamoutte CE, Rosa-Casilla ND, Meléndez-Berrios DE. Breaking Barriers: The Design and Development of an Assistive Technology Web App for Older Latinos with Disabilities in Daily Activities. Technologies (Basel). 2024 Nov;12(11):232. doi: 10.3390/technologies12110232. Epub 2024 Nov 19.
• Monero-Paredes M, Santiago E, Carrasquillo-Carrion K, Renta JY, Rogozin IB, Roche-Lima A, Duconge J. Paraoxonase-1 as a Cardiovascular Biomarker in Caribbean Hispanic Patients Treated with Clopidogrel: Abundance and Functionality. Int J Mol Sci. 2024 Oct 3;25(19):10657. doi: 10.3390/ijms251910657.
• Vélez-López O, Carrasquillo-Carrion K, Cantres-Rosario YM, Machín-Martínez E, Álvarez-Ríos ME, Roche-Lima A, Tosado-Rodríguez EL, Meléndez LM. Analysis of Sigma-1 Receptor Antagonist BD1047 Effect on Upregulating Proteins in HIV-1-Infected Macrophages Exposed to Cocaine Using Quantitative Proteomics. Biomedicines. 2024 Aug 23;12(9):1934. doi: 10.3390/biomedicines12091934.
• LeBien J, Velev J, Roche-Lima A. Indirect reference interval estimation using a convolutional neural network with application to cancer antigen 125. Sci Rep. 2024 Aug 20;14(1):19332. doi: 10.1038/s41598-024-70074-6.
• Frances Heredia-Negrón, Eduardo L. Tosado-Rodríguez, Joshua Meléndez-Berrios, Brenda Nieves, Claudia P. Amaya-Ardila and Abiel Roche-Lima. Assessing the Impact of AI Education on Hispanic Healthcare Professionals' Perceptions and Knowledge Educ. Sci. 2024, 14(4), 339; https://doi.org/10.3390/educsci14040339.
• Roche-Lima A, Rosado-Quiñones AM, Feliu-Maldonado RA, Figueroa-Gispert MDM, Díaz-Rivera J, Díaz-González RG, Carrasquillo-Carrion K, Nieves BG, Colón-Lorenzo EE, Serrano AE. Antimalarial Drug Combination Predictions Using the Machine Learning Synergy Predictor (MLSyPred©) tool. Acta Parasitol. 2024 Jan 2. doi: 10.1007/s11686-023-00765-z. Epub ahead of print. PMID: 38165555.
• Velev J, LeBien J, Roche-Lima A. Unsupervised machine learning method for indirect estimation of reference intervals for chronic kidney disease in the Puerto Rican population. Sci Rep. 2023 Oct 11;13(1):17198. doi: 10.1038/s41598-023-43830-3. PMID: 37821500; PMCID: PMC10567761
• Monero-Paredes M, Feliu-Maldonado R, Carrasquillo-Carrion K, Gonzalez P, Rogozin IB, Roche-Lima A, Duconge J. Non-Random Enrichment of Single-Nucleotide Polymorphisms Associated with Clopidogrel Resistance within Risk Loci Linked to the Severity of Underlying Cardiovascular Diseases: The Role of Admixture. Genes (Basel). 2023 Sep 17;14(9):1813. doi: 10.3390/genes14091813. PMID: 37761953; PMCID: PMC10531115.
• Alvare G, Roche-Lima A, Fristensky B. BioLegato: a programmable, object-oriented graphic user interface. BMC Bioinformatics. 2023 Aug 21;24(1):316. doi: 10.1186/s12859-023-05436-4. PMID: 37605108; PMCID: PMC10441721.
• Rebello BC, Ramirez ARG, Heredia-Negron F, Roche-Lima A. A machine learning-based approach to epileptic seizure prediction using electro-encephalographic signals. J Eng Res (Ponta Grossa). 2022;2(8):10.22533/at.ed.317282219056. doi: 10.22533/at.ed.317282219056. PMID: 35711293; PMCID: PMC9199360.
• Heredia FL, Roche-Lima A, Parés-Matos EI. A novel artificial intelligence-based approach for identification of deoxynucleotide aptamers. PLoS Comput Biol. 2021 Aug 3;17(8):e1009247. doi: 10.1371/journal.pcbi.1009247. PMID: 34343165; PMCID: PMC8362955.
• Hernandez-Suarez DF, Ranka S, Kim Y, Latib A, Wiley J, Lopez-Candales A, Pinto DS, Gonzalez MC, Ramakrishna H, Sanina C, Nieves-Rodriguez BG, Rodriguez-Maldonado J, Feliu Maldonado R, Rodriguez-Ruiz IJ, da Luz Sant'Ana I, Wiley KA, Cox-Alomar P, Villablanca PA, Roche-Lima A. Machine-Learning-Based In-Hospital Mortality Prediction for Transcatheter Mitral Valve Repair in the United States. Cardiovasc Revasc Med. 2021 Jan;22:22-28. doi: 10.1016/j.carrev.2020.06.017. Epub 2020 Jun 15. PMID: 32591310; PMCID: PMC7736498.
• Zenón-Meléndez CN, Carrasquillo Carrión K, Cantres Rosario Y, Roche Lima A, Meléndez LM. Inhibition of Cathepsin B and SAPC Secreted by HIV-Infected Macrophages Reverses Common and Unique Apoptosis Pathways. J Proteome Res. 2022 Feb 4;21(2):301-312. doi: 10.1021/acs.jproteome.1c00187. Epub 2022 Jan 7. PMID: 34994563; PMCID: PMC9169015.
• Borges-Vélez G, Rosado-Philippi J, Cantres-Rosario YM, Carrasquillo-Carrion K, Roche-Lima A, Pérez-Vargas J, González-Martínez A, Correa-Rivas MS, Meléndez LM. Zika virus infection of the placenta alters extracellular matrix proteome. J Mol Histol. 2022 Apr;53(2):199-214. doi: 10.1007/s10735-021-09994-w. Epub 2021 Jul 15. PMID: 34264436; PMCID: PMC8760362.
• Gonzalez-Cordero AF, Duconge-Soler J, Franqui-Rivera H, Feliu-Maldonado R, Roche-Lima A, Almodovar-Rivera I. Insight on the Genetics of Atrial Fibrillation in Puerto Rican Hispanics. Stroke Res Treat. 2021 Jan 7;2021:8819896. doi: 10.1155/2021/8819896. PMID: 33505650; PMCID: PMC7810540.
• Borges-Vélez G, Arroyo JA, Cantres-Rosario YM, Rodriguez de Jesus A, Roche-Lima A, Rosado-Philippi J, Rosario-Rodríguez LJ, Correa-Rivas MS, Campos-Rivera M, Meléndez LM. Decreased CSTB, RAGE, and Axl Receptor Are Associated with Zika Infection in the Human Placenta. Cells. 2022 Nov 16;11(22):3627. doi: 10.3390/cells11223627. PMID: 36429055; PMCID: PMC9688057.
• Heredia-Negron F, Alamo-Rodriguez N, Oyola-Velazquez L, Nieves B, Carrasquillo K, Hochheiser H, Fristensky B, Daluz-Santana I, Fernandez-Repollet E, Roche-Lima A. Evaluation of AIML + HDR-A Course to Enhance Data Science Workforce Capacity for Hispanic Biomedical Researchers. Int J Environ Res Public Health. 2023 Feb 3;20(3):2726. doi: 10.3390/ijerph20032726. PMID: 36768092; PMCID: PMC9914971.
• Awad CS, Deng Y, Kwagyan J, Roche-Lima A, Tchounwou PB, Wang Q, Idris MY. Summary of Year-One Effort of the RCMI Consortium to Enhance Research Capacity and Diversity with Data Science. Int J Environ Res Public Health. 2022 Dec 24;20(1):279. doi: 10.3390/ijerph20010279. PMID: 36612607; PMCID: PMC9819075.
• Bykova A, Saura A, Glazko GV, Roche-Lima A, Yurchenko V, Rogozin IB. The 29-nucleotide deletion in SARS-CoV: truncated versions of ORF8 are under purifying selection. BMC Genomics. 2023 Jul 10;24(1):387. doi: 10.1186/s12864-023-09482-3. PMID: 37430204; PMCID: PMC10332002.
• Martínez-Matías N, Chorna N, González-Crespo S, Villanueva L, Montes-Rodríguez I, Melendez-Aponte LM, Roche-Lima A, Carrasquillo-Carrión K, Santiago-Cartagena E, Rymond BC, Babu M, Stagljar I, Rodríguez-Medina JR. Toward the discovery of biological functions associated with the mechanosensor Mtl1p of Saccharomyces cerevisiae via integrative multi-OMICs analysis. Sci Rep. 2021 Apr 1;11(1):7411. doi: 10.1038/s41598-021-86671-8. PMID: 33795741; PMCID: PMC8016984.
• Tchounwou PB, Malouhi M, Ofili EO, Fernández-Repollet E, Sarpong DF, Yanagihara R, Aguilera RJ, Ayón C, Chen X, Dasmahapatra A, Gao S, Hinton CV, Holt R, Kolesnichenko V, Powell MD, Merchant F, Redda KK, Roche-Lima A, Shikuma CM, Stevens JJ, Torres JA, Trotter RT, Wachira J, Wang P, Wells KJ, White J, Wu Y. Research Infrastructure Core Facilities at Research Centers in Minority Institutions: Part I-Research Resources Management, Operation, and Best Practices. Int J Environ Res Public Health. 2022 Dec 17;19(24):16979. doi: 10.3390/ijerph192416979. PMID: 36554864; PMCID: PMC9779820.
• Rabelo-Fernández RJ, Santiago-Sánchez GS, Sharma RK, Roche-Lima A, Carrion KC, Rivera RAN, Quiñones-Díaz BI, Rajasekaran S, Siddiqui J, Miles W, Rivera YS, Valiyeva F, Vivas-Mejia PE. Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells. Int J Mol Sci. 2022 Jan 4;23(1):535. doi: 10.3390/ijms23010535. PMID: 35008958; PMCID: PMC8745614.
• Rogozin IB, Roche-Lima A, Tyryshkin K, Carrasquillo-Carrión K, Lada AG, Poliakov LY, Schwartz E, Saura A, Yurchenko V, Cooper DN, Panchenko AR, Pavlov YI. DNA Methylation, Deamination, and Translesion Synthesis Combine to Generate Footprint Mutations in Cancer Driver Genes in B-Cell Derived Lymphomas and Other Cancers. Front Genet. 2021 May 19;12:671866. doi: 10.3389/fgene.2021.671866. PMID: 34093666; PMCID: PMC8170131.
• Roche-Lima A, Roman-Santiago A, Roberto Feliu-Maldonado R, Jovaniel Rodriguez-Maldonado R, Nieves-Rodriguez BG, Carrasquillo-Carrion K, Ramos C.M., da Luz Sant'Ana I, Massey S.E., Duconge J. . Machine Learning Algorithm for Predicting Warfarin Dose in Caribbean Hispanics Using Pharmacogenetic Data. Front Pharmacol 2020. PMID: 32038238 PMCID: PMC6987072 DOI: 10.3389/fphar.2019.01550
• Hernandez-Suarez DF, Villablanca PA, Kim Y, Wiley J, Sanina C, Roche-Lima A. Reply: Leveraging Machine Learning to Generate Prediction Models for Structural Valve Interventions. PMID: 31648770 PMCID: PMC7011192 (available on 2020-10-28) DOI: 10.1016/j.jcin.2019.09.001
• Hernandez-Suarez DF, Kim Y, Villablanca P, Gupta T, Wiley J, Nieves-Rodriguez BG, Rodriguez-Maldonado J, Feliu Maldonado R, da Luz Sant'Ana I, Sanina C, Cox-Alomar P, Ramakrishna H, Lopez-Candales A, O'Neill WW, Pinto DS, Latib A, Roche-Lima A. Machine Learning Prediction Models for In-Hospital Mortality After Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv. 2019 Jul 22;12(14):1328-1338. doi: 10.1016/j.jcin.2019.06.013. PMID: 31320027
• Gómez-Moreno R, Martínez-Ramírez R, Roche-Lima A, Carrasquillo-Carrión K, Pérez-Santiago J, Baerga-Ortiz A. Hotspots of Sequence Variability in Gut Microbial Genes Encoding Pro-Inflammatory Factors Revealed by Oligotyping. Front Genet. 2019 Jul 9;10:631. doi: 10.3389/fgene.2019.00631. eCollection 2019. PMID: 31354787
• Graydon JS, Claudio K, Baker S, Kocherla M, Ferreira M, Roche-Lima A, Rodríguez-Maldonado J, Duconge J, Ruaño G. Ethnogeographic prevalence and implications of the 677C>T and 1298A>C MTHFR polymorphisms in US primary care populations. Biomark Med. 2019 Jun;13(8):649-661. doi: 10.2217/bmm-2018-0392. Epub 2019 Jun 3. PMID: 31157538
• Hernandez-Suarez DF, Lopez-Menendez F, Roche-Lima A, Lopez-Candales A. Assessment of Mitral Annular Plane Systolic Excursion in Patients With Left Ventricular Diastolic Dysfunction. Cardiol Res. 2019 Apr;10(2):83-88. doi: 10.14740/cr837. Epub 2019 Apr 11. PMID: 31019637
• Hernandez-Suarez DF, Ranka S, Villablanca P, Yordan-Lopez N, González-Sepúlveda L, Wiley J, Sanina C, Roche-Lima A, Nieves-Rodriguez BG, Thomas S, Cox-Alomar P, Lopez-Candales A, Ramakrishna H. Racial/Ethnic Disparities in Patients Undergoing Transcatheter Aortic Valve Replacement: Insights from the Healthcare Cost and Utilization Project's National Inpatient Sample. Cardiovasc Revasc Med. 2019 Jul;20(7):546-552. doi: 10.1016/j.carrev.2019.04.005. Epub 2019 Apr 9. PMID: 30987828
• Rogozin IB, Roche-Lima A, Lada AG, Belinky F, Sidorenko IA, Glazko GV, Babenko VN, Cooper DN, Pavlov YI. Nucleotide Weight Matrices Reveal Ubiquitous Mutational Footprints of AID/APOBEC Deaminases in Human Cancer Genomes. Cancers (Basel). 2019 Feb 12;11(2). pii: E211. doi: 10.3390/cancers11020211. PMID: 30759888
• Vélez-Segarra, V., Carrasquillo-Carrión, K., Santini-González, J. J., Ramos-Valerio, Y. A., Vázquez-Quiñones, L. E., Roche-Lima, A., Rodriguez-Medina, J.R., Parés-Matos, E. I. (2019). Modelling and molecular docking studies of the cytoplasmic domain of Wsc-family, full-length Ras2p, and therapeutic antifungal compounds. Computational Biology and Chemistry, 78, 338-352. doi:10.1016/j.compbiolchem.2019.01.001
• Claudio-Campos, K.I., González-Santiago, P., Renta, J.Y., Roche-Lima, A., Rodriguez Maldonado, J., Carrasquillo-Carrión, K., Gaedigk, A., Duconge, J. CYP2C9*61, a rare missense variant in exon 9, identified in a Puerto Rican patient with low warfarin dose requirements: A Case Report. Pharmacogenomics, 2018.
• Roche-Lima, A., Carrasquillo-Carrion, K., Gomez-Moreno, R., Cruz, J.M., Velazquez-Morales, D., Rogozin, I.B., Baerga-Ortiz, A. (2018) The presence of genotoxic and/or pro-inflammatory bacterial genes in gut metagenomic databases and their possible link with inflammatory bowel diseases, Frontiers in Genetics, Vol 9, pp116, doi: 10.3389/fgene.2018.00116.
• Manfredi, B, Morales-Ortíz, J., Díaz-Díaz, L.M., Hernandez-Matias, L., Barreto-Vázquez, D., Menéndez-Pérez, J., Rodríguez-Cordero, J.A., Villalobos-Santos, J.C., Santiago-Rivera, E., Rivera-Dompenciel, A., Lozada-Delgado, E.L., Kuchibhotla, M., Carrasquillo-Carrión, K., Roche-Lima, A., Washington, A.V. (2018). Characterization of monoclonal antibodies to mouse TLT-1 suggests that TLT-1 plays a role in wound healing. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. Vol. 37, No. 2.
• Ordoñez, P., Schwarz, N., Figueroa Jiménez, A., García Lebrón, L., Roche Lima, A.; Learning stochastic finite-state transducer to predict individual patient outcomes. Published at Journal of Health and Technology (2016). 6:239. doi:10.1007/s12553-016-0146-2. First published online: October 17, 2016.
• Roche Lima, A. (2016). Implementation and comparison of kernel-based learning methods to predict metabolic networks. Network Modeling Analysis in Health Informatics and Bioinformatics. 5: 26. doi:10.1007/s13721-016-0134-5.
• Roche-Lima, A.; Domaratzki, M., Fristensky, B. (2014). Metabolic Network Prediction Through Pairwise Rational Kernels. BMC Bioinformatics 2014, 15:318. doi:10.1186/1471-2105-15-318. (1380 visits in 3 months).
• Roche-Lima, A.; Domaratzki, M., Fristensky, B. (2014). Pairwise Rational Kernels Obtained by Automaton Operations. Submitted to CIAA'2014. International Conference of Implementation and Application of Automata. Febrero 2014. Volume 8587, 2014, pp 332-345.
• Auriemma WS, Berger AC, Bar-Ad V, Boland PM, Cohen SJ, S CM, Roche-Lima A, Morris GJ. Locally Advanced Pancreatic Cancer. PMID: 22846869 DOI: 10.1053/j.seminoncol.2012.05.015
• Alvare GG, Roche-Lima A, Fristensky B. BioPCD - A Language for GUI Development Requiring a Minimal Skill Set. PMID: 27818582 PMCID: PMC5096648
• Roche-Lima A, Thulasiram RK. Bioinformatics Algorithm Based on a Parallel Implementation of a Machine Learning Approach Using Transducers. PMID: 27795731 PMCID: PMC5082745 DOI: 10.1088/1742-6596/341/1/012034